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Cas No. 1118767-16-0, Semaglutide side chain

  • 1118767-16-0

  • C43H79N3O13

  • 846.1

  • 1.079±0.06

  • 98% min (HPLC)

  • Pale Yellow Oil

  • Semaglutide

  • 2/17/2041 (Semaglutide)

  • GLP-1

  • N

  • 100 kg Batch quantity

  • 40 kg

  • tons

Availability:
Cas No. 1118767-16-0, Semaglutide side chain

Supply Chain

The Supply Chain Status in China

As of August 20, 2024, there are 128 potential suppliers manufacturing Semaglutide intermediate tBuO-Ste-Glu(AEEA-AEEA-OH)-OtBu (CAS No. 1118767-16-0), including 37 traders, 72 factories and 19 labs, among which:

- The 25th percentile has an average registered capital of 1 million CNY;

- The 50th percentile has an average registerd capital of 5 million CNY;

-  The 75th percentile has an average registered capital of 10 million CNY.


Feeling overwhelmed? Contact Unibest if you need us to quality-check other sources to strengthen your supply chain or to find a tailored solution for your specific procurement request.

Usage and ROS Analysis


Structure of tBuO-Ste-Glu(AEEA-AEEA-OH)-OtBu


tBuO-Ste-Glu(AEEA-AEEA-OH)-OtBu, CAS No. 1118767-16-0, is an Semaglutide side chain composed of the C18 fatty acid (CAS No. 871-70-5) and AEEA dimer (CAS No. 1143516-05-5).



CAS No. 1118767-16-0 Structure



The Overall Synthesis Map of Semaglutide Side Chain

Semaglutide side chain ROS

There are two routes that would yield Semaglutide side chain CAS No. 1662688-20-1. One is through solid-phase synthesis (lower part) while the other is not (upper part). Both routes converge into this Semaglutide side chain tBuO-Ste-Glu(AEEA-AEEA-OH)-OtBu, CAS No. 1118767-16-0.


The solid phase synthesis building blocks involves three moieties including Fmoc-AEEA (CAS No. 166108-71-0), Fmoc-Glu-OtBu (CAS No. 84793-07-7), and mono-tBu-stearate (CAS No. 843666-40-0). 


The other route does not involve solid phase synthesis. It starts from the C18 fatty acid (CAS No. 871-70-5) and attaches the fatty acid with Glu, and AEEA-dimer. 



References


1.
Kjeldsen, T. B. et al. Engineering of Orally Available, Ultralong-Acting Insulin Analogues: Discovery of OI338 and OI320. J. Med. Chem. 64, 616–628 (2021).
 
2.
Eidelman, C., Penias-Navon, S. & Naveh, L. Improved Processes for the Preparation of Semaglutide. (2020).
 
3.
Madsen, P. et al. Protease stabilized acylated insulin analogues. (2017).
 
4.
张伟 et al. 种制备脂肪二酸衍生物的方法及其应用. (2018).
 
5.
Kopach, M. E., Lu, Y., Tsukanov, S. V. & White, T. D. Methods of Making Incretin Analogs. (2021).


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