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Cas No. 843666-40-0, Semaglutide side chain

  • 843666-40-0

  • C22H42O4

  • 370.6

  • 0.950±0.06

  • 98% min (HPLC)

  • 68

  • White to off-white powder

  • Semaglutide

  • 2/17/2041 (Semaglutide)

  • GLP-1

  • N

  • 500 kg Batch quantity

  • 25 kg

  • 20 tons

  • 2019

  • ISO 9001;ISO 14001;ISO 45001

Availability:
Cas No. 843666-40-0, Semaglutide side chain

Supply Chain

The Supply Chain Status in China

As of August 26, 2024, there are 202 potential suppliers manufacturing Semaglutide intermediate mono-tBu stearate (CAS No. 843666-40-0), including 52 traders, 113 factories and 37 labs, among which:

- The 25th percentile has an average registered capital of 1 million CNY;

- The 50th percentile has an average registerd capital of 3 million CNY;

-  The 75th percentile has an average registered capital of 10 million CNY.


Feeling overwhelmed? Contact Unibest if you need us to quality-check other sources to strengthen your supply chain or to find a tailored solution for your specific procurement request.

Usage and ROS Analysis


Structure of mono-tBu-stearate


mono-tBu-stearate, CAS No. 843666-40-0, is an Semaglutide side chain synthesized from the C18 fatty acid (CAS No. 871-70-5).



mono-tBu-stearate



The Overall Synthesis Map of Semaglutide Side Chain

Semaglutide side chain ROS

There are two routes that would yield Semaglutide side chain CAS No. 1662688-20-1. One is through solid-phase synthesis (lower part) while the other is not (upper part). Both routes converge into this Semaglutide side chain tBuO-Ste-Glu(AEEA-AEEA-OH)-OtBu, CAS No. 1118767-16-0.


The solid phase synthesis building blocks involves three moieties including Fmoc-AEEA (CAS No. 166108-71-0), Fmoc-Glu-OtBu (CAS No. 84793-07-7), and this compound mono-tBu-stearate (CAS No. 843666-40-0). 


The other route does not involve solid phase synthesis. It starts from the C18 fatty acid (CAS No. 871-70-5), giving the mono-tBu-stearate. Then mono-tBu-stearate attaches with Glu, and AEEA-dimer. 



References


1.
Kjeldsen, T. B. et al. Engineering of Orally Available, Ultralong-Acting Insulin Analogues: Discovery of OI338 and OI320. J. Med. Chem. 64, 616–628 (2021).
 
2.
Eidelman, C., Penias-Navon, S. & Naveh, L. Improved Processes for the Preparation of Semaglutide. (2020).
 
3.
Madsen, P. et al. Protease stabilized acylated insulin analogues. (2017).
 
4.
张伟 et al. 种制备脂肪二酸衍生物的方法及其应用. (2018).
 
5.
Kopach, M. E., Lu, Y., Tsukanov, S. V. & White, T. D. Methods of Making Incretin Analogs. (2021).


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