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6228-73-5
C4H7NO
85.10
Psoriasis
Deucravacitinib
11/7/2033 (Deucravacitinib)
tyrosine kinase 2
Y
Supply Chain
Based on the proriasis market analysis, the 2023 demand for this intermediate cyclopropanecarboxamide (CAS No. 6228-73-5) was esimated to be 1.17 Kg, depending on the specific route. Considering the deeper market penetration and the completion of Deucravacitinib clinical trials on other diseases, the demand is to grow.
As of July 29, 2024, there are 94 potential suppliers manufacturing Deucravacitinib intermediate cyclopropanecarboxamide (CAS No. 6228-73-5), including 65 factories and 25 labs, among which:
- The 25th percentile has an average registered capital of 1 million CNY;
- The 50th percentile has an average registerd capital of 5 million CNY;
- The 75th percentile has an average registered capital of 15 million CNY.
Feeling overwhelmed? Contact Unibest if you need us to quality-check other sources to strengthen your supply chain or to find a tailored solution for your specific procurement request.
Usage and ROS Analysis
Deucravacitinib, CAS No. 1609392-27-9, is a deuterated compound, and structurally speaking, four scaffolds can be identified:
- a benzene - triazole scaffold (scaffold A)
- a deuterated pyridazine (scaffold B + scaffold C)
- a three membered ring (scaffold D)
This compound, cyclopropanecarboxamide, CAS No. 6228-73-5, is the three-memered ring scaffold (scaffold D) of Deucravacitinib as shown below.
This compound forms the three-member ring in the Deucravacitinib API. It reacts with the chloride leaving group on the Deucravacitinib main chain.
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Liu, J. et al. Tyrosine Kinase 2 (tyk2) Degradation Compounds and Methods of Use. (2022).
Greenwood, J. R. et al. Tyk2 Inhibitors and Uses Thereof. (2018).
Šagud, I. et al. Solid State Forms of Deucravacitinib, Deucravacitinib Hcl and Process for Preparation of Deucravacitinib and Intermediates. (2023).
Chen, K. et al. Process for the Preparation of 6-(cyclopropaneamido)-4-((2-Methoxy-3-(1-Methyl-1h-1,2,4-Triazol-3-Yl)phenyl)amino)-N-(methyl-D3)pyridazine-3-Carboxamide. (2018).
Li, P., Wang, P., Zhou, P., Zhao, X. & Wei, Q. Method for Synthesizing Deucravacitinib. (2024).
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