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1609394-10-6
C10H12N4O
204.23
1.29±0.1
98.0% min (HPLC)
229-232
Off-white solid
Psoriasis
Deucravacitinib
11/7/2033 (Deucravacitinib)
tyrosine kinase 2
N
2023
Generic Gient Audited
Supply Chain
Based on the proriasis market analysis, the 2023 demand for this intermediate 2-methoxy-3-(1-methyl-1,2,4-triazol-3-yl)aniline (CAS No. 1609394-10-6) was esimated to range from 2.97 Kg to 4.25 Kg, depending on the specific route. Considering the deeper market penetration and the completion of Deucravacitinib clinical trials on other diseases, the demand is to grow.
As of July 29, 2024, there are 100 potential suppliers manufacturing Deucravacitinib intermediate 2-methoxy-3-(1-methyl-1,2,4-triazol-3-yl)aniline (CAS No. 1609394-10-6), including 86 factories and 11 labs, among which:
- The 25th percentile has an average registered capital of 1 million CNY;
- The 50th percentile has an average registerd capital of 3 million CNY;
- The 75th percentile has an average registered capital of 10 million CNY.
Feeling overwhelmed? Contact Unibest if you need us to quality-check other sources to strengthen your supply chain or to find a tailored solution for your specific procurement request.
Usage and ROS Analysis
Deucravacitinib, CAS No. 1609392-27-9, is a deuterated compound, and structurally speaking, four scaffolds can be identified:
- a benzene - triazole scaffold (scaffold A)
- a deuterated pyridazine (scaffold B + scaffold C)
- a three membered ring (scaffold D)
This compound, 2-methoxy-3-(1-methyl-1,2,4-triazol-3-yl)aniline, CAS No. 1609394-10-6, contributes to the benzene-triazole scaffold of Deucravacitinib as shown below.
The amine group on this Deucravacitinib intermediate is to react with a chloride leaving group on the scaffold B/C (such as CAS No.1609393-89-6 and CAS No. 2245238-80-4), forming the backbone of Deucravacitinib API.
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Liu, J. et al. Tyrosine Kinase 2 (tyk2) Degradation Compounds and Methods of Use. (2022).
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Šagud, I. et al. Solid State Forms of Deucravacitinib, Deucravacitinib Hcl and Process for Preparation of Deucravacitinib and Intermediates. (2023).
Chen, K. et al. Process for the Preparation of 6-(cyclopropaneamido)-4-((2-Methoxy-3-(1-Methyl-1h-1,2,4-Triazol-3-Yl)phenyl)amino)-N-(methyl-D3)pyridazine-3-Carboxamide. (2018).
Li, P., Wang, P., Zhou, P., Zhao, X. & Wei, Q. Method for Synthesizing Deucravacitinib. (2024).
Wang, W. et al. Hydroxamate Compound, Preparation Method Therefor and Application Thereof. (2022).
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